Explore signaling pathway data in highly active aberrant malignancies. Published in high-impact journals, such as Cancer Cell and Nature Communications, these datasets contain information on supervillain cells revealing insights into the functional mechanisms of resistance and disease progression.
|Proliferation||NK Cells||Preclinical Discovery||CCL22 mutations drive natural killer cell lymphoproliferative disease by deregulating microenvironmental crosstalk||Nature Genetics, 2022||Single-Cell Intracellular Proteome: HeLa Cell|
|Resistance||Melanoma||Preclinical Discovery||Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line||Nature Communications, 2020||Tumor Cell|
|Resistance||Melanoma||Preclinical Discovery||Single-cell analysis resolves the cell state transition and signaling dynamics associated with melanoma drug-induced resistance||PNAS, 2017||Tumor Cell|
|Resistance||Glioblastoma||Preclinical Discovery||Single-Cell Phosphoproteomics Resolves Adaptive Signaling Dynamics and Informs Targeted Combination Therapy in Glioblastoma||Cancer Cell, 2016||Tumor Cell|