Supercharged Immunology

Superhero Cell

Explore data from highly polyfunctional superpowered cells responsible for orchestrating immune responses in vivo. Published in high-impact journals such as the Journal of Clinical Oncology and Nature Medicine, these datasets contain information on superhero cells whose function is predictive of patient response and survival.

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Mouse Bone Marrow (BM) CD117+ (cKIT) Cells Human Tumor Associated Endothelial Cell (EC) Human NK Cell Mouse Monocyte Human Tumor Associated Fibroblasts Human CD154+ T Cell Mouse T-Cells with PMA & Ionomycin Human CD34+ Myeloid Stem Cell HeLa Cell Human PBMC with PMA & Ionomycin Mouse T-cells Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8 Human PBMC Human Bispecific TCR-T Human Monocyte Using Membrane Stain

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Biomarker	Cell Type	Application	Publication	Journal & Year	Protocol
Persistence Potency	CAR-T	Preclinical Discovery	A long-acting interleukin-7, rhIL-7-hyFc, enhances CAR T cell expansion, persistence, and anti-tumor activity	Nature Communications, 2022	IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Response Persistence	CAR-T	Clinical Biomarker	Single-cell antigen-specific landscape of CAR T infusion product identifies determinants of CD19-positive relapse in patients with ALL	Science Advances, 2022	IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Response Potency	CAR-T	Clinical Biomarker	Bispecific targeting of CD20 and CD19 increases polyfunctionality of chimeric antigen receptor T-cell products in B-cell malignancies	Cytotherapy, 2022	IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647- Conjugated Antibodies to CD4 and CD8
Potency Survival	CAR-T	Preclinical Discovery	Cytosine Base Editing Enables Quadruple-Edited Allogeneic CAR-T Cells for T-ALL \| Blood \| American Society of Hematology	Blood, 2022	IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647- Conjugated Antibodies to CD4 and CD8
Potency Survival	TCR-T	Preclinical Discovery	T-Cells Expressing a Highly Potent PRAME-Specific T-Cell Receptor in Combination with a Chimeric PD1-41BB Co-Stimulatory Receptor Show a Favorable Preclinical Safety Profile and Strong Anti-Tumor Reactivity	Cancers, 2022	IsoCode Single-Cell Adaptive Immune: TCR‑T
Response	Myeloid Cells	Clinical Biomarker	Cell-directed aptamer therapeutic targeting for cancers including those within the central nervous system	Oncoimmunology, 2022	IsoCode Single-Cell Innate Immune: Human Monocyte Using Membrane Stain
Response	T-Cells	Clinical Biomarker	Ipilimumab alone or in combination with nivolumab in patients with advanced melanoma who have progressed or relapsed on PD-1 blockade: clinical outcomes and translational biomarker analyses	JITC, 2022	IsoCode Single-Cell Adaptive Immune: Human PBMC
Response Survival	T-Cells	Clinical Biomarker	Prognostic Value of Early Fluorodeoxyglucose-Positron Emission Tomography Response Imaging and Peripheral Immunologic Biomarkers: Substudy of a Phase II Trial of Risk-Adaptive Chemoradiation for Unresectable Non-Small Cell Lung Cancer	Advances in Radiation Oncology, 2021	IsoCode Single-Cell Adaptive Immune: Human PBMC
Potency	CAR-T	Preclinical Discovery	Benign tumors in TSC are amenable to treatment by GD3 CAR T cells in mice	JCI Insight , 2021	IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Persistence Potency	CAR-T	Preclinical Discovery	4-1BB and optimized CD28 co-stimulation enhances function of human mono-specific and bi-specific third-generation CAR T cells	Journal for Immunotherapy of Cancer, 2021	IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Response Survival	T-Cells	Clinical Biomarker	Single-cell polyfunctional proteomics of CD4 cells from patients with AML predicts responses to anti–PD-1–based therapy	Blood Advances, 2021	IsoCode Single-Cell Adaptive Immune: Human PBMC
Potency	TILs	Manufacturing & Product QC, Clinical Biomarker	Tumor-infiltrating lymphocyte treatment for anti-PD-1-resistant metastatic lung cancer: a phase 1 trial	Nature Medicine, 2021	IsoCode Single-Cell Adaptive Immune: Human T-Cell
Potency	CAR-T	Manufacturing & Product QC, Clinical Biomarker	CAR T cells with dual targeting of CD19 and CD22 in adult patients with recurrent or refractory B cell malignancies: a phase 1 trial	Nature Medicine, 2021	IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Efficacy	NK Cells	Preclinical Discovery	Tumor-derived NKG2D ligand sMIC reprograms NK cells to an inflammatory phenotype through CBM signalosome activation	Communications Biology, 2021	IsoCode Single-Cell Adaptive Immune: Human NK Cell
Fitness Response	T-Cells	Preclinical Discovery, Clinical Biomarker	Venetoclax enhances T cell–mediated antileukemic activity by increasing ROS production	Blood, 2021	IsoCode Single-Cell Adaptive Immune: Human PBMC
Response Survival	T-Cells	Clinical Biomarker	Bempegaldesleukin Plus Nivolumab in First-Line Metastatic Melanoma	Journal of Clinical Oncology, 2021	IsoCode Single-Cell Adaptive Immune: Human PBMC
Potency	NK Cells	Preclinical Discovery	Transient blockade of TBK1/IKKε allows efficient transduction of primary human natural killer cells with vesicular stomatitis virus G-pseudotyped lentiviral vectors	Cytotherapy, 2021	IsoCode Single-Cell Adaptive Immune: Human NK Cell
Potency	NK Cells	Preclinical Discovery	NF-κB c-Rel Is Dispensable for the Development but Is Required for the Cytotoxic Function of NK Cells	Frontiers in Immunology, 2021	IsoCode Single-Cell Adaptive Immune: Human NK Cell
Potency	CAR-T	Preclinical Discovery	Mesenchymal stromal cell delivery of oncolytic immunotherapy improves CAR-T cell antitumor activity	Molecular Therapy, 2021	IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Potency	T-Cells	Preclinical Discovery, Clinical Biomarker	Use of Multi-Site Radiation Therapy for Systemic Disease Control	International Journal of Radiation Oncology, Biology, Physics, 2021	IsoCode Single-Cell Adaptive Immune: Human PBMC
Response	T-Cells	Clinical Biomarker	Changes in peripheral and local tumor immunity after neoadjuvant chemotherapy reshape clinical outcomes in patients with breast cancer	Clinical Cancer Research, 2020	IsoCode Single-Cell Adaptive Immune: Human PBMC
Potency	T-Cells	Preclinical Discovery	Targeted Co-delivery of Tumor Antigen and α-Galactosylceramide to CD141+ Dendritic Cells Induces a Potent Tumor Antigen-Specific Human CD8+ T Cell Response in Human Immune System Mice	Frontiers in Immunology, 2020	IsoCode Single-Cell Adaptive Immune: Human PBMC
Persistence Potency	NK Cells	Preclinical Discovery	Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes in vivo Persistence and Enhances Anti-tumor Activity	Cell Stem Cell, 2020	IsoCode Single-Cell Adaptive Immune: Human NK Cell
Potency	CAR-T	Preclinical Discovery	CAR T-cells that target acute B-lineage leukemia irrespective of CD19 expression	Leukemia, 2020	IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Persistence Potency	CAR-T	Preclinical Discovery	Persistent Polyfunctional Chimeric Antigen Receptor T Cells That Target Glypican 3 Eliminate Orthotopic Hepatocellular Carcinomas in Mice	Gastroenterology, 2020	IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Persistence Potency	T-Cells, NK Cells	Preclinical Discovery, Clinical Biomarker	Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist	Nature Communications, 2020	IsoCode Single-Cell Adaptive Immune: Human PBMC
Potency	CAR-T	Preclinical Discovery	Rational design of a trimeric APRIL-based CAR-binding domain enables efficient targeting of multiple myeloma	Blood Advances, 2019	IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Response	CAR-T	Clinical Biomarker, Manufacturing & Product QC	Preinfusion Polyfunctional Anti-CD19 Chimeric Antigen Receptor T Cells Associate with Clinical Outcomes in NHL	Blood, 2018	IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Potency	T-Cells	Preclinical Discovery, Clinical Biomarker	A Kinetic Investigation of Interacting, Stimulated T Cells Identifies Conditions for Rapid Functional Enhancement, Minimal Phenotype Differentiation, and Improved Adoptive Cell Transfer Tumor Eradication	PLOS One, 2018	IsoCode Single-Cell Adaptive Immune: Human PBMC with PMA & Ionomycin