Supercharged Immunology
Superhero Cell

Explore data from highly polyfunctional superpowered cells responsible for orchestrating immune responses in vivo. Published in high-impact journals such as the Journal of Clinical Oncology and Nature Medicine, these datasets contain information on superhero cells whose function is predictive of patient response and survival.

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OVERVIEW

Explore the Cell Library
Supercharged Immunology by Cell Types, Applications & Biomarkers
  • Preclinical Bioprocessing
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  • Preclinical Discovery
  • Preclinical Discovery
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Our Unique Biology

Detect our most powerful cells with functional proteomics.

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Virtual Lab Tour

Explore our all-in-one integrated system, sample to answers.

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Data Visualizations

Generate publication-ready data visualizations in seconds.

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Cell Data
Persistence T-Cells Clinical Biomarker Multiomics and spatial mapping characterizes human CD8+ T cell states in cancer Science Translational Medicine, 2023 IsoCode Single-Cell Adaptive Immune: Human PBMC
Response
Potency
CAR-T Preclinical Discovery The IgG4 hinge with CD28 transmembrane domain improves VHH-based CAR T cells targeting a membrane-distal epitope of GPC1 in pancreatic cancer Nature Communications, 2023 IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Response
Potency
T-Cells Preclinical Discovery Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal antitumor immunity Science Immunology, 2023 IsoCode Single-Cell Adaptive Immune: Mouse T-cells Protocol
Response T-Cells Preclinical Discovery Immunotoxin-αCD40 therapy activates innate and adaptive immunity and generates a durable antitumor response in glioblastoma models Science Translational Medicine, 2023 IsoCode Single-Cell Adaptive Immune: Human PBMC
Response
Potency
NK Cells Preclinical Discovery Synapse-tuned CARs enhance immune cell anti-tumor activity Nature Biotechnology, 2023 IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Response NK Cells Clinical Biomarker Metformin increases natural killer cell functions in head and neck squamous cell carcinoma through CXCL1 inhibition Journal for Immunotherapy of Cancer, 2022 IsoCode Single-Cell Adaptive Immune: Human NK Cell
Response T-Cells Clinical Biomarker First-in-human phase I/II, open-label study of the anti-OX40 agonist INCAGN01949 in patients with advanced solid tumors Journal for Immunotherapy of Cancer, 2022 IsoCode Single-Cell Adaptive Immune: Human PBMC
Persistence
Potency
CAR-T Preclinical Discovery Secreted Fas Decoys Enhance the Antitumor Activity of Engineered and Bystander T Cells in Fas Ligand–Expressing Solid Tumors Cancer Immunology Research, 2022 IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Potency T-Cells Manufacturing & Product QC Enabling Allogeneic T Cell-Based Therapies: Scalable Stirred-Tank Bioreactor Mediated Manufacturing Frontiers in Medical Technology, 2022 IsoCode Single-Cell Adaptive Immune: Human PBMC
Potency T-Cells Preclinical Discovery Transgenic Expression of IL15 Retains CD123-Redirected T Cells in a Less Differentiated State Resulting in Improved Anti-AML Activity in Autologous AML PDX Models Frontiers in Immunology, 2022 IsoCode Single-Cell Adaptive Immune: Human PBMC
Persistence
Potency
CAR-T Preclinical Discovery A long-acting interleukin-7, rhIL-7-hyFc, enhances CAR T cell expansion, persistence, and anti-tumor activity Nature Communications, 2022 IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Response
Persistence
CAR-T Clinical Biomarker Single-cell antigen-specific landscape of CAR T infusion product identifies determinants of CD19-positive relapse in patients with ALL Science Advances, 2022 IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Response
Potency
CAR-T Clinical Biomarker Bispecific targeting of CD20 and CD19 increases polyfunctionality of chimeric antigen receptor T-cell products in B-cell malignancies Cytotherapy, 2022 IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Potency
Survival
CAR-T Preclinical Discovery Cytosine Base Editing Enables Quadruple-Edited Allogeneic CAR-T Cells for T-ALL | Blood | American Society of Hematology Blood, 2022 IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Potency
Survival
TCR-T Preclinical Discovery T-Cells Expressing a Highly Potent PRAME-Specific T-Cell Receptor in Combination with a Chimeric PD1-41BB Co-Stimulatory Receptor Show a Favorable Preclinical Safety Profile and Strong Anti-Tumor Reactivity Cancers, 2022 IsoCode Single-Cell Adaptive Immune: TCR‑T
Response Myeloid Cells Clinical Biomarker Cell-directed aptamer therapeutic targeting for cancers including those within the central nervous system Oncoimmunology, 2022 IsoCode Single-Cell Innate Immune: Human Monocyte Using Membrane Stain
Response T-Cells Clinical Biomarker Ipilimumab alone or in combination with nivolumab in patients with advanced melanoma who have progressed or relapsed on PD-1 blockade: clinical outcomes and translational biomarker analyses JITC, 2022 IsoCode Single-Cell Adaptive Immune: Human PBMC
Response
Survival
T-Cells Clinical Biomarker Prognostic Value of Early Fluorodeoxyglucose-Positron Emission Tomography Response Imaging and Peripheral Immunologic Biomarkers: Substudy of a Phase II Trial of Risk-Adaptive Chemoradiation for Unresectable Non-Small Cell Lung Cancer Advances in Radiation Oncology, 2021 IsoCode Single-Cell Adaptive Immune: Human PBMC
Potency CAR-T Preclinical Discovery Benign tumors in TSC are amenable to treatment by GD3 CAR T cells in mice JCI Insight, 2021 IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Persistence
Potency
CAR-T Preclinical Discovery 4-1BB and optimized CD28 co-stimulation enhances function of human mono-specific and bi-specific third-generation CAR T cells Journal for Immunotherapy of Cancer, 2021 IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Response
Survival
T-Cells Clinical Biomarker Single-cell polyfunctional proteomics of CD4 cells from patients with AML predicts responses to anti–PD-1–based therapy Blood Advances, 2021 IsoCode Single-Cell Adaptive Immune: Human PBMC
Potency TILs Manufacturing & Product QC, Clinical Biomarker Tumor-infiltrating lymphocyte treatment for anti-PD-1-resistant metastatic lung cancer: a phase 1 trial Nature Medicine, 2021 IsoCode Single-Cell Adaptive Immune: Human T-Cell
Potency CAR-T Manufacturing & Product QC, Clinical Biomarker CAR T cells with dual targeting of CD19 and CD22 in adult patients with recurrent or refractory B cell malignancies: a phase 1 trial Nature Medicine, 2021 IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Efficacy NK Cells Preclinical Discovery Tumor-derived NKG2D ligand sMIC reprograms NK cells to an inflammatory phenotype through CBM signalosome activation Communications Biology, 2021 IsoCode Single-Cell Adaptive Immune: Human NK Cell
Fitness
Response
T-Cells Preclinical Discovery, Clinical Biomarker Venetoclax enhances T cell–mediated antileukemic activity by increasing ROS production Blood, 2021 IsoCode Single-Cell Adaptive Immune: Human PBMC
Response
Survival
T-Cells Clinical Biomarker Bempegaldesleukin Plus Nivolumab in First-Line Metastatic Melanoma Journal of Clinical Oncology, 2021 IsoCode Single-Cell Adaptive Immune: Human PBMC
Potency NK Cells Preclinical Discovery Transient blockade of TBK1/IKKε allows efficient transduction of primary human natural killer cells with vesicular stomatitis virus G-pseudotyped lentiviral vectors Cytotherapy, 2021 IsoCode Single-Cell Adaptive Immune: Human NK Cell
Potency NK Cells Preclinical Discovery NF-κB c-Rel Is Dispensable for the Development but Is Required for the Cytotoxic Function of NK Cells Frontiers in Immunology, 2021 IsoCode Single-Cell Adaptive Immune: Human NK Cell
Potency CAR-T Preclinical Discovery Mesenchymal stromal cell delivery of oncolytic immunotherapy improves CAR-T cell antitumor activity Molecular Therapy, 2021 IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Potency T-Cells Preclinical Discovery, Clinical Biomarker Use of Multi-Site Radiation Therapy for Systemic Disease Control International Journal of Radiation Oncology, Biology, Physics, 2021 IsoCode Single-Cell Adaptive Immune: Human PBMC
Response T-Cells Clinical Biomarker Changes in peripheral and local tumor immunity after neoadjuvant chemotherapy reshape clinical outcomes in patients with breast cancer Clinical Cancer Research, 2020 IsoCode Single-Cell Adaptive Immune: Human PBMC
Potency T-Cells Preclinical Discovery Targeted Co-delivery of Tumor Antigen and α-Galactosylceramide to CD141+ Dendritic Cells Induces a Potent Tumor Antigen-Specific Human CD8+ T Cell Response in Human Immune System Mice Frontiers in Immunology, 2020 IsoCode Single-Cell Adaptive Immune: Human PBMC
Persistence
Potency
NK Cells Preclinical Discovery Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes in vivo Persistence and Enhances Anti-tumor Activity Cell Stem Cell, 2020 IsoCode Single-Cell Adaptive Immune: Human NK Cell
Potency CAR-T Preclinical Discovery CAR T-cells that target acute B-lineage leukemia irrespective of CD19 expression Leukemia, 2020 IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Persistence
Potency
CAR-T Preclinical Discovery Persistent Polyfunctional Chimeric Antigen Receptor T Cells That Target Glypican 3 Eliminate Orthotopic Hepatocellular Carcinomas in Mice Gastroenterology, 2020 IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Persistence
Potency
T-Cells, NK Cells Preclinical Discovery, Clinical Biomarker Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist Nature Communications, 2020 IsoCode Single-Cell Adaptive Immune: Human PBMC
Potency CAR-T Preclinical Discovery Rational design of a trimeric APRIL-based CAR-binding domain enables efficient targeting of multiple myeloma Blood Advances, 2019 IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Response CAR-T Clinical Biomarker, Manufacturing & Product QC Preinfusion Polyfunctional Anti-CD19 Chimeric Antigen Receptor T Cells Associate with Clinical Outcomes in NHL Blood, 2018 IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Potency T-Cells Preclinical Discovery, Clinical Biomarker A Kinetic Investigation of Interacting, Stimulated T Cells Identifies Conditions for Rapid Functional Enhancement, Minimal Phenotype Differentiation, and Improved Adoptive Cell Transfer Tumor Eradication PLOS One, 2018 IsoCode Single-Cell Adaptive Immune: Human PBMC with PMA & Ionomycin