Supercharged Immunology
Superhero Cell

Explore data from highly polyfunctional superpowered cells responsible for orchestrating immune responses in vivo. Published in high-impact journals such as the Journal of Clinical Oncology and Nature Medicine, these datasets contain information on superhero cells whose function is predictive of patient response and survival.

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OVERVIEW

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Supercharged Immunology by Cell Types, Applications & Biomarkers
  • Preclinical Bioprocessing
  • Preclinical Manufacturing
  • Product Quality Control
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  • Preclinical Discovery
  • Preclinical Discovery
  • Preclinical Discovery
Our Unique Biology

Detect our most powerful cells with functional proteomics.

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Data Visualizations

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Cell Data
Persistence
Potency
CAR-T Preclinical Discovery A long-acting interleukin-7, rhIL-7-hyFc, enhances CAR T cell expansion, persistence, and anti-tumor activity Nature Communications, 2022 IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Response
Persistence
CAR-T Clinical Biomarker Single-cell antigen-specific landscape of CAR T infusion product identifies determinants of CD19-positive relapse in patients with ALL Science Advances, 2022 IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Response
Potency
CAR-T Clinical Biomarker Bispecific targeting of CD20 and CD19 increases polyfunctionality of chimeric antigen receptor T-cell products in B-cell malignancies Cytotherapy, 2022 IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647- Conjugated Antibodies to CD4 and CD8
Potency
Survival
CAR-T Preclinical Discovery Cytosine Base Editing Enables Quadruple-Edited Allogeneic CAR-T Cells for T-ALL | Blood | American Society of Hematology Blood, 2022 IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647- Conjugated Antibodies to CD4 and CD8
Potency
Survival
TCR-T Preclinical Discovery T-Cells Expressing a Highly Potent PRAME-Specific T-Cell Receptor in Combination with a Chimeric PD1-41BB Co-Stimulatory Receptor Show a Favorable Preclinical Safety Profile and Strong Anti-Tumor Reactivity Cancers, 2022 IsoCode Single-Cell Adaptive Immune: TCR‑T
Response Myeloid Cells Clinical Biomarker Cell-directed aptamer therapeutic targeting for cancers including those within the central nervous system Oncoimmunology, 2022 IsoCode Single-Cell Innate Immune: Human Monocyte Using Membrane Stain
Response T-Cells Clinical Biomarker Ipilimumab alone or in combination with nivolumab in patients with advanced melanoma who have progressed or relapsed on PD-1 blockade: clinical outcomes and translational biomarker analyses JITC, 2022 IsoCode Single-Cell Adaptive Immune: Human PBMC
Response
Survival
T-Cells Clinical Biomarker Prognostic Value of Early Fluorodeoxyglucose-Positron Emission Tomography Response Imaging and Peripheral Immunologic Biomarkers: Substudy of a Phase II Trial of Risk-Adaptive Chemoradiation for Unresectable Non-Small Cell Lung Cancer Advances in Radiation Oncology, 2021 IsoCode Single-Cell Adaptive Immune: Human PBMC
Potency CAR-T Preclinical Discovery Benign tumors in TSC are amenable to treatment by GD3 CAR T cells in mice JCI Insight , 2021 IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Persistence
Potency
CAR-T Preclinical Discovery 4-1BB and optimized CD28 co-stimulation enhances function of human mono-specific and bi-specific third-generation CAR T cells Journal for Immunotherapy of Cancer, 2021 IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Response
Survival
T-Cells Clinical Biomarker Single-cell polyfunctional proteomics of CD4 cells from patients with AML predicts responses to anti–PD-1–based therapy Blood Advances, 2021 IsoCode Single-Cell Adaptive Immune: Human PBMC
Potency TILs Manufacturing & Product QC, Clinical Biomarker Tumor-infiltrating lymphocyte treatment for anti-PD-1-resistant metastatic lung cancer: a phase 1 trial Nature Medicine, 2021 IsoCode Single-Cell Adaptive Immune: Human T-Cell
Potency CAR-T Manufacturing & Product QC, Clinical Biomarker CAR T cells with dual targeting of CD19 and CD22 in adult patients with recurrent or refractory B cell malignancies: a phase 1 trial Nature Medicine, 2021 IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Efficacy NK Cells Preclinical Discovery Tumor-derived NKG2D ligand sMIC reprograms NK cells to an inflammatory phenotype through CBM signalosome activation Communications Biology, 2021 IsoCode Single-Cell Adaptive Immune: Human NK Cell
Fitness
Response
T-Cells Preclinical Discovery, Clinical Biomarker Venetoclax enhances T cell–mediated antileukemic activity by increasing ROS production Blood, 2021 IsoCode Single-Cell Adaptive Immune: Human PBMC
Response
Survival
T-Cells Clinical Biomarker Bempegaldesleukin Plus Nivolumab in First-Line Metastatic Melanoma Journal of Clinical Oncology, 2021 IsoCode Single-Cell Adaptive Immune: Human PBMC
Potency NK Cells Preclinical Discovery Transient blockade of TBK1/IKKε allows efficient transduction of primary human natural killer cells with vesicular stomatitis virus G-pseudotyped lentiviral vectors Cytotherapy, 2021 IsoCode Single-Cell Adaptive Immune: Human NK Cell
Potency NK Cells Preclinical Discovery NF-κB c-Rel Is Dispensable for the Development but Is Required for the Cytotoxic Function of NK Cells Frontiers in Immunology, 2021 IsoCode Single-Cell Adaptive Immune: Human NK Cell
Potency CAR-T Preclinical Discovery Mesenchymal stromal cell delivery of oncolytic immunotherapy improves CAR-T cell antitumor activity Molecular Therapy, 2021 IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Potency T-Cells Preclinical Discovery, Clinical Biomarker Use of Multi-Site Radiation Therapy for Systemic Disease Control International Journal of Radiation Oncology, Biology, Physics, 2021 IsoCode Single-Cell Adaptive Immune: Human PBMC
Response T-Cells Clinical Biomarker Changes in peripheral and local tumor immunity after neoadjuvant chemotherapy reshape clinical outcomes in patients with breast cancer Clinical Cancer Research, 2020 IsoCode Single-Cell Adaptive Immune: Human PBMC
Potency T-Cells Preclinical Discovery Targeted Co-delivery of Tumor Antigen and α-Galactosylceramide to CD141+ Dendritic Cells Induces a Potent Tumor Antigen-Specific Human CD8+ T Cell Response in Human Immune System Mice Frontiers in Immunology, 2020 IsoCode Single-Cell Adaptive Immune: Human PBMC
Persistence
Potency
NK Cells Preclinical Discovery Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes in vivo Persistence and Enhances Anti-tumor Activity Cell Stem Cell, 2020 IsoCode Single-Cell Adaptive Immune: Human NK Cell
Potency CAR-T Preclinical Discovery CAR T-cells that target acute B-lineage leukemia irrespective of CD19 expression Leukemia, 2020 IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Persistence
Potency
CAR-T Preclinical Discovery Persistent Polyfunctional Chimeric Antigen Receptor T Cells That Target Glypican 3 Eliminate Orthotopic Hepatocellular Carcinomas in Mice Gastroenterology, 2020 IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Persistence
Potency
T-Cells, NK Cells Preclinical Discovery, Clinical Biomarker Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist Nature Communications, 2020 IsoCode Single-Cell Adaptive Immune: Human PBMC
Potency CAR-T Preclinical Discovery Rational design of a trimeric APRIL-based CAR-binding domain enables efficient targeting of multiple myeloma Blood Advances, 2019 IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Response CAR-T Clinical Biomarker, Manufacturing & Product QC Preinfusion Polyfunctional Anti-CD19 Chimeric Antigen Receptor T Cells Associate with Clinical Outcomes in NHL Blood, 2018 IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Potency T-Cells Preclinical Discovery, Clinical Biomarker A Kinetic Investigation of Interacting, Stimulated T Cells Identifies Conditions for Rapid Functional Enhancement, Minimal Phenotype Differentiation, and Improved Adoptive Cell Transfer Tumor Eradication PLOS One, 2018 IsoCode Single-Cell Adaptive Immune: Human PBMC with PMA & Ionomycin