Hyper
Inflammation
SuperVillain Cell

Explore data from highly polyfunctional supervillain cells responsible for promoting disease in vivo. Published in high-impact journals such as Cell and Blood, these datasets contain information on supervillain cells whose function is predictive of inflammation and toxicity.

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Hyperinflammation by Cell Types, Applications & Biomarkers
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Cell Data
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Allorejection T-Cells Clinical Biomarker Effector Memory–Expressing CD45RA (TEMRA) CD8+ T Cells from Kidney Transplant Recipients Exhibit Enhanced Purinergic P2X4 Receptor–Dependent Proinflammatory and Migratory Responses JASN, 2022 IsoCode Single-Cell Adaptive Immune: Human PBMC
Inflammation
Response 		Monocytes Preclinical Discovery Inhibition of integrin αVβ3 signaling improves the antineoplastic effect of bexarotene in cutaneous T-cell lymphoma Molecular Cancer Therapeutics, 2022 IsoCode Single-Cell Innate Immune: Human Monocyte Using Membrane Stain
Inflammation Macrophages Preclinical Discovery Analyzing immune response to engineered hydrogels by hierarchical clustering of inflammatory cell subsets Science Advances, 2022 IsoCode Single-Cell Adaptive Immune: Human PBMC
Inflammation T-Cells, NK Cells, Monocytes Clinical Biomarker Multiple Early Factors Anticipate Post-Acute COVID-19 Sequelae Cell, 2022 IsoCode Single-Cell Innate Immune: Human Monocyte Using Membrane Stain
Inflammation NK Cells Preclinical Discovery Tumor-derived NKG2D ligand sMIC reprograms NK cells to an inflammatory phenotype through CBM signalosome activation Communications Biology, 2021 IsoCode Single-Cell Adaptive Immune: Human NK Cell
Allorejection T-Cells Preclinical Discovery Complement-activated human endothelial cells stimulate increased polyfunctionality in alloreactive T cells American Journal of Transplantation, 2021 IsoCode Single-Cell Adaptive Immune: Human PBMC
Inflammation T-Cells, Monocytes Clinical Biomarker Multi-omics resolves a sharp disease-state shift between mild and moderate COVID-19 Cell, 2020 IsoCode Single-Cell Adaptive Immune: Human PBMC
Pathogenesis Monocytes, Macrophages Clinical Biomarker SIRPα expression delineates subsets of intratumoral monocyte/macrophages with different functional and prognostic impact in follicular lymphoma Blood Cancer Journal, 2019 IsoCode Single-Cell Innate Immune: Human Monocyte Using Membrane Stain
CNS Inflammation Monocytes Clinical Biomarker Enhanced TLR2 Responses in Multiple Sclerosis Clinical and Experimental Immunology, 2018 IsoCode Single-Cell Innate Immune: Human Monocyte Using Membrane Stain
CRS CAR-T Clinical Biomarker, Manufacturing & Product QC Preinfusion Polyfunctional Anti-CD19 Chimeric Antigen Receptor T Cells Associate with Clinical Outcomes in NHL Blood, 2018 IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Pathogenesis Bone Marrow Cells Preclinical Discovery, Clinical Biomarker JAK–STAT Pathway Activation in Malignant and Nonmalignant Cells Contributes to MPN Pathogenesis and Therapeutic Response Cancer Discovery, 2015 IsoCode Single-Cell Innate Immune: Human CD34+ Myeloid Stem Cell
Inflammation NK Cells Clinical Biomarker Human NK Cells Licensed by Killer Ig Receptor Genes Have an Altered Cytokine Program That Modifies CD4+ T Cell Function The Journal of Immunology, 2014 IsoCode Single-Cell Adaptive Immune: Human NK Cell