Supercharged Immunology

Superhero Cell

Explore data from highly polyfunctional superpowered cells responsible for orchestrating immune responses in vivo. Published in high-impact journals such as the Journal of Clinical Oncology and Nature Medicine, these datasets contain information on superhero cells whose function is predictive of patient response and survival.

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Mouse Bone Marrow (BM) CD117+ (cKIT) Cells Human Tumor Associated Endothelial Cell (EC) Human NK Cell Mouse Monocyte Human Tumor Associated Fibroblasts Human CD154+ T Cell Mouse T-Cells with PMA & Ionomycin Human CD34+ Myeloid Stem Cell HeLa Cell Human PBMC with PMA & Ionomycin Mouse T-cells Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8 Human PBMC Human Bispecific TCR-T Human Monocyte Using Membrane Stain

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Biomarker	Cell Type	Application	Publication	Journal & Year	Protocol
Persistence	T-Cells	Clinical Biomarker	Multiomics and spatial mapping characterizes human CD8+ T cell states in cancer	Science Translational Medicine, 2023	IsoCode Single-Cell Adaptive Immune: Human PBMC
Response Potency	CAR-T	Preclinical Discovery	The IgG4 hinge with CD28 transmembrane domain improves VHH-based CAR T cells targeting a membrane-distal epitope of GPC1 in pancreatic cancer	Nature Communications, 2023	IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Response Potency	T-Cells	Preclinical Discovery	Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal antitumor immunity	Science Immunology, 2023	IsoCode Single-Cell Adaptive Immune: Mouse T-cells Protocol
Response	T-Cells	Preclinical Discovery	Immunotoxin-αCD40 therapy activates innate and adaptive immunity and generates a durable antitumor response in glioblastoma models	Science Translational Medicine, 2023	IsoCode Single-Cell Adaptive Immune: Human PBMC
Response Potency	NK Cells	Preclinical Discovery	Synapse-tuned CARs enhance immune cell anti-tumor activity	Nature Biotechnology, 2023	IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Response	NK Cells	Clinical Biomarker	Metformin increases natural killer cell functions in head and neck squamous cell carcinoma through CXCL1 inhibition	Journal for Immunotherapy of Cancer, 2022	IsoCode Single-Cell Adaptive Immune: Human NK Cell
Response	T-Cells	Clinical Biomarker	First-in-human phase I/II, open-label study of the anti-OX40 agonist INCAGN01949 in patients with advanced solid tumors	Journal for Immunotherapy of Cancer, 2022	IsoCode Single-Cell Adaptive Immune: Human PBMC
Persistence Potency	CAR-T	Preclinical Discovery	Secreted Fas Decoys Enhance the Antitumor Activity of Engineered and Bystander T Cells in Fas Ligand–Expressing Solid Tumors	Cancer Immunology Research, 2022	IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Potency	T-Cells	Manufacturing & Product QC	Enabling Allogeneic T Cell-Based Therapies: Scalable Stirred-Tank Bioreactor Mediated Manufacturing	Frontiers in Medical Technology, 2022	IsoCode Single-Cell Adaptive Immune: Human PBMC
Potency	T-Cells	Preclinical Discovery	Transgenic Expression of IL15 Retains CD123-Redirected T Cells in a Less Differentiated State Resulting in Improved Anti-AML Activity in Autologous AML PDX Models	Frontiers in Immunology, 2022	IsoCode Single-Cell Adaptive Immune: Human PBMC
Persistence Potency	CAR-T	Preclinical Discovery	A long-acting interleukin-7, rhIL-7-hyFc, enhances CAR T cell expansion, persistence, and anti-tumor activity	Nature Communications, 2022	IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Response Persistence	CAR-T	Clinical Biomarker	Single-cell antigen-specific landscape of CAR T infusion product identifies determinants of CD19-positive relapse in patients with ALL	Science Advances, 2022	IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Response Potency	CAR-T	Clinical Biomarker	Bispecific targeting of CD20 and CD19 increases polyfunctionality of chimeric antigen receptor T-cell products in B-cell malignancies	Cytotherapy, 2022	IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Potency Survival	CAR-T	Preclinical Discovery	Cytosine Base Editing Enables Quadruple-Edited Allogeneic CAR-T Cells for T-ALL \| Blood \| American Society of Hematology	Blood, 2022	IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Potency Survival	TCR-T	Preclinical Discovery	T-Cells Expressing a Highly Potent PRAME-Specific T-Cell Receptor in Combination with a Chimeric PD1-41BB Co-Stimulatory Receptor Show a Favorable Preclinical Safety Profile and Strong Anti-Tumor Reactivity	Cancers, 2022	IsoCode Single-Cell Adaptive Immune: TCR‑T
Response	Myeloid Cells	Clinical Biomarker	Cell-directed aptamer therapeutic targeting for cancers including those within the central nervous system	Oncoimmunology, 2022	IsoCode Single-Cell Innate Immune: Human Monocyte Using Membrane Stain
Response	T-Cells	Clinical Biomarker	Ipilimumab alone or in combination with nivolumab in patients with advanced melanoma who have progressed or relapsed on PD-1 blockade: clinical outcomes and translational biomarker analyses	JITC, 2022	IsoCode Single-Cell Adaptive Immune: Human PBMC
Response Survival	T-Cells	Clinical Biomarker	Prognostic Value of Early Fluorodeoxyglucose-Positron Emission Tomography Response Imaging and Peripheral Immunologic Biomarkers: Substudy of a Phase II Trial of Risk-Adaptive Chemoradiation for Unresectable Non-Small Cell Lung Cancer	Advances in Radiation Oncology, 2021	IsoCode Single-Cell Adaptive Immune: Human PBMC
Potency	CAR-T	Preclinical Discovery	Benign tumors in TSC are amenable to treatment by GD3 CAR T cells in mice	JCI Insight, 2021	IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Persistence Potency	CAR-T	Preclinical Discovery	4-1BB and optimized CD28 co-stimulation enhances function of human mono-specific and bi-specific third-generation CAR T cells	Journal for Immunotherapy of Cancer, 2021	IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Response Survival	T-Cells	Clinical Biomarker	Single-cell polyfunctional proteomics of CD4 cells from patients with AML predicts responses to anti–PD-1–based therapy	Blood Advances, 2021	IsoCode Single-Cell Adaptive Immune: Human PBMC
Potency	TILs	Manufacturing & Product QC, Clinical Biomarker	Tumor-infiltrating lymphocyte treatment for anti-PD-1-resistant metastatic lung cancer: a phase 1 trial	Nature Medicine, 2021	IsoCode Single-Cell Adaptive Immune: Human T-Cell
Potency	CAR-T	Manufacturing & Product QC, Clinical Biomarker	CAR T cells with dual targeting of CD19 and CD22 in adult patients with recurrent or refractory B cell malignancies: a phase 1 trial	Nature Medicine, 2021	IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Efficacy	NK Cells	Preclinical Discovery	Tumor-derived NKG2D ligand sMIC reprograms NK cells to an inflammatory phenotype through CBM signalosome activation	Communications Biology, 2021	IsoCode Single-Cell Adaptive Immune: Human NK Cell
Fitness Response	T-Cells	Preclinical Discovery, Clinical Biomarker	Venetoclax enhances T cell–mediated antileukemic activity by increasing ROS production	Blood, 2021	IsoCode Single-Cell Adaptive Immune: Human PBMC
Response Survival	T-Cells	Clinical Biomarker	Bempegaldesleukin Plus Nivolumab in First-Line Metastatic Melanoma	Journal of Clinical Oncology, 2021	IsoCode Single-Cell Adaptive Immune: Human PBMC
Potency	NK Cells	Preclinical Discovery	Transient blockade of TBK1/IKKε allows efficient transduction of primary human natural killer cells with vesicular stomatitis virus G-pseudotyped lentiviral vectors	Cytotherapy, 2021	IsoCode Single-Cell Adaptive Immune: Human NK Cell
Potency	NK Cells	Preclinical Discovery	NF-κB c-Rel Is Dispensable for the Development but Is Required for the Cytotoxic Function of NK Cells	Frontiers in Immunology, 2021	IsoCode Single-Cell Adaptive Immune: Human NK Cell
Potency	CAR-T	Preclinical Discovery	Mesenchymal stromal cell delivery of oncolytic immunotherapy improves CAR-T cell antitumor activity	Molecular Therapy, 2021	IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Potency	T-Cells	Preclinical Discovery, Clinical Biomarker	Use of Multi-Site Radiation Therapy for Systemic Disease Control	International Journal of Radiation Oncology, Biology, Physics, 2021	IsoCode Single-Cell Adaptive Immune: Human PBMC
Response	T-Cells	Clinical Biomarker	Changes in peripheral and local tumor immunity after neoadjuvant chemotherapy reshape clinical outcomes in patients with breast cancer	Clinical Cancer Research, 2020	IsoCode Single-Cell Adaptive Immune: Human PBMC
Potency	T-Cells	Preclinical Discovery	Targeted Co-delivery of Tumor Antigen and α-Galactosylceramide to CD141+ Dendritic Cells Induces a Potent Tumor Antigen-Specific Human CD8+ T Cell Response in Human Immune System Mice	Frontiers in Immunology, 2020	IsoCode Single-Cell Adaptive Immune: Human PBMC
Persistence Potency	NK Cells	Preclinical Discovery	Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes in vivo Persistence and Enhances Anti-tumor Activity	Cell Stem Cell, 2020	IsoCode Single-Cell Adaptive Immune: Human NK Cell
Potency	CAR-T	Preclinical Discovery	CAR T-cells that target acute B-lineage leukemia irrespective of CD19 expression	Leukemia, 2020	IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Persistence Potency	CAR-T	Preclinical Discovery	Persistent Polyfunctional Chimeric Antigen Receptor T Cells That Target Glypican 3 Eliminate Orthotopic Hepatocellular Carcinomas in Mice	Gastroenterology, 2020	IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Persistence Potency	T-Cells, NK Cells	Preclinical Discovery, Clinical Biomarker	Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist	Nature Communications, 2020	IsoCode Single-Cell Adaptive Immune: Human PBMC
Potency	CAR-T	Preclinical Discovery	Rational design of a trimeric APRIL-based CAR-binding domain enables efficient targeting of multiple myeloma	Blood Advances, 2019	IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Response	CAR-T	Clinical Biomarker, Manufacturing & Product QC	Preinfusion Polyfunctional Anti-CD19 Chimeric Antigen Receptor T Cells Associate with Clinical Outcomes in NHL	Blood, 2018	IsoCode Single-Cell Adaptive Immune: Human CAR-T Using AF647-Conjugated Antibodies to CD4 and CD8
Potency	T-Cells	Preclinical Discovery, Clinical Biomarker	A Kinetic Investigation of Interacting, Stimulated T Cells Identifies Conditions for Rapid Functional Enhancement, Minimal Phenotype Differentiation, and Improved Adoptive Cell Transfer Tumor Eradication	PLOS One, 2018	IsoCode Single-Cell Adaptive Immune: Human PBMC with PMA & Ionomycin